“Some of you may have heard or read the FDA's recent announcement regarding the safety of Nexgard, Bravecto, Simparica, and Credelio. These are all drugs classified as Isoxazolines and are used for the treatment and prevention of fleas and ticks in dogs and cats. These products listed have been approved by the FDA as safe and effective when used as directed by the manufacturer and your veterinarian. This article was produced to ensure the awareness of the potential for an adverse neurological events in cats and dogs, and that you should always consult your Veterinarian before giving these preventatives to your pets. Please read the attachment below for more information on this topic or call our office at 208-333-7730.”

https://www.fda.gov/AnimalVeterinary/ResourcesforYou/AnimalHealthLiteracy/ucm620940.htm

Simparica’s adverse event profile continues to be predictable, consistent with pre-approval studies and looks similar to other isoxazoline products on the market

The most commonly reported adverse events for Simparica released by Zoetis are:

             Vomiting

             Diarrhea

             Lethargy

All Simparica clinical signs coded in these cases were reported as very rare (defined as less than 1 report per 10,000 doses administered).